RESUMEN El síndrome de Miescher-Melkerson-Rosenthal es una condición clínica poco frecuente caracterizada por un edema orofacial episódico, paresia facial periférica recurrente, lengua geográfica (lingua plicata) y granulomas en biopsia de piel o labial. Se ha reportado más frecuentemente en mujeres, y su incidencia es probablemente subestimada por el desconocimiento del síndrome, su presentación clínica incompleta y la plétora de diagnósticos diferenciales. Se debe considerar en pacientes que presenten al menos dos de las cuatro características mencionadas. Su tratamiento, con esteroides vía oral, está dirigido a los episodios de edema orofacial y/o paresia facial. A continuación se describen tres casos del síndrome valorados en el servicio de neurología de la Fundación Cardioinfantil y se presenta una breve revisión de la literatura.

SUMMARY Miescher-Melkerson-Rosenthal syndrome is an uncommon clinical condition characterized by episodic orofacial oedema, recurrent peripheral facial paralysis, geographic tongue (lingua plicata) and granulomas in skin or labial biopsy. It is reported more frequently in women, and its incidence is probably underestimated due to lack of knowledge of the syndrome, incomplete clinical presentation and the plethora of differential diagnosis. It should be considered in patients with at least two of the four mentioned characteristics. Its treatment, with oral steroids, is directed at the episodes of orofacial oedema and/or the facial paralysis. We described three cases of the syndrome seen at the Fundacion Cardioinfantil's neurology service and present a short review of the literature.

Objective: To evaluate the internal validity of a health sciences graduate program curriculum. Materials and methods: A descriptive study using a documentary analysis of a public university’s Master of Education and Health Research Program. The internal validity was analyzed through the identification of professional profile indicators, subjects’ syllabi were rated, and the congruence in the curriculum map was assessed. Personality (alpha) and occupational (beta) indicators were considered. Descriptive statistics was performed using Microsoft Excel 2013. Results: Alpha indicators such as the ability to design, demonstrate, assess and apply, and beta indicators such as being a leader, researcher, professor and assessor were identified. The syllabi achieved a passing grade, but deficiencies in the methodology, materials and bibliography were observed. The indicators "knowledge", "application", "being a researcher and professor" were interrelated in the curriculum map; however, indicators such as "assessment", "communication", "being a leader and assessor" were not interrelated. Conclusions: The proposed professional profile is represented in the curriculum, but the indicators are not adequately interrelated

Objetivo: Evaluar la validez interna del currículo de un programa de posgrado en ciencias de la salud. Materiales y métodos: Estudio descriptivo con análisis documental de un programa de maestría en Docencia e Investigación en Salud de una universidad pública. Se analizó la validez interna mediante identificación de indicadores del perfil profesional, se calificaron los sílabos de las asignaturas y se valoró la congruencia en mapa curricular. Se consideraron indicadores de personalidad (alfa) y ocupacionales (beta). Se calculó estadística descriptiva con Microsoft Excel 2013. Resultados: Se identificaron indicadores alfa (diseña, demuestra, valora y aplica) e indicadores beta (líder, investigador, docente y evaluador). Los sílabos tuvieron calificación aprobatoria, pero deficiencias en metodología, materiales y bibliografía. Los indicadores conocimiento, aplicación, ser investigador y docente, estaban articulados en el mapa curricular, y se detectó desarticulación de indicadores de valoración, comunicación, ser líder y evaluador. Conclusiones: El perfil profesional planteado está representado en el plan curricular, pero los indicadores no están articulados adecuadamente

ABSTRACT This study was carried out to investigate the potentialities of the application of membrane technology in biodiesel purification without need of the decantation step. A new composite UF membrane was prepared from poly(vinylidene fluoride) casting solution (17 wt%) containing a sulfonated Carbon (20 wt%). The assays were performed in a dead-end filtration cell with synthetic mixtures of the transesterification reaction products. The influence of two operational variables was analyzed, transmembrane pressure (∆P = 4-8 bar) and temperature (T = 50-60°C). The membrane performance was evaluated determining the flux and the permeate compositions. Temperature resulted to be the most important operational variable. An increase in 10°C duplicated the permeate flux at 6 and 8 bar. The best performance was obtained at 60°C and 8 bar, with a flux of 12.6 Lm-2h-1. In this operative conditions, the influence of the added acidified water (Wadd = 0-20 %v/v) in the synthetic mixture was evaluated, which increased considerably permeate fluxes. Finally, the impact of synthetic mixture composition was determined for the assayed best operational conditions. The higher flux value was measured in the mixture with less glycerol and without soaps. In all assays the biodiesel retention was complete and the permeates were composed mainly of glycerol and ethanol.

El presente trabajo de investigación, consiste en la elaboración de un Plan de Gestión Integral para el manejo de residuos sólidos en la empresa Cyrgo SAS, cuyo objetivo general radica en la formulación de dicho Plan. La metodología diseñada es Investigación de Tipo Descriptivo Exploratorio con enfoque mixto; cualitativo - cuantitativo y se construye con un diagnóstico completo realizado en cuanto al manejo actual de residuos sólidos en la empresa, con el fin de establecer las medidas a implementar y estructurar un Plan de seguimiento a las actividades propuestas. Los resultados obtenidos a través del trabajo de campo e interacción con las diferentes personas y áreas objeto de estudio, permiten obtener un documento con el conjunto de medidas a implementar para que la empresa lo adopte y de alguna u otra forma pueda disminuir los impactos ambientales negativos que se puedan generar por un inadecuado manejo de residuos sólidos.

This research work is the development of an Integrated Management Plan for solid waste management in the company Cyrgo SAS, whose overall objective is to formulate the plan. The research methodology is designed descriptive exploratory type with mixed approach; qualitative - quantitative and built with a complete diagnosis made on the current solid waste management in the company, in order to establish the measures to implement and structure a monitoring plan proposed activities. The results obtained through fieldwork and interaction with different people and areas under study; allow obtaining a document with a set of measures to implement for the company to adopt it and some way to reduce the negative environmental impacts that may arise from improper handling of solid waste.

Este trabalho de investigação é a desenvolver de um plano de gestão abrangente para gestão de resíduos sólidos na companhia Cyrgo SAS, cujo objetivo geral encontra-se na formulação do plano. A metodologia projetado é pesquisa descritiva exploratório com abordagem mista descritiva; Qualitativo - quantitativa e constrói um diagnóstico completo feito sobre a atual gestão de resíduos sólidos na empresa, a fim de estabelecer as medidas a implementar e estruturar um plano de monitoramento propostos atividades. Os resultados obtidos através do trabalho de campo e interação com pessoas diferentes e áreas em estudo, permitem obter um documento com o conjunto de medidas a serem implementadas pela empresa para adotá-la e de alguma outra forma pode reduzir os impactos ambientais negativos que podem surgir a partir de manuseio inadequado de resíduos sólidos.

ABSTRACT Lumbar puncture in neurologically asymptomatic HIV+ patients is still under debate. There are different criteria for detecting neurosyphilis through cerebrospinal fluid (CSF), especially in cases that are negative through the Venereal Disease Research Laboratory (VDRL), regarding cellularity and protein content. However, a diagnosis of neurosyphilis can still exist despite negative VDRL. Treponema pallidum hemagglutination assay (TPHA) titers and application of the TPHA index in albumin and IgG improve the sensitivity, with a high degree of specificity. Thirty-two patients were selected for this study. VDRL was positive in five of them. The number of diagnoses reached 14 when the other techniques were added. It was not determined whether cellularity and increased protein levels were auxiliary tools in the diagnosis. According to our investigation, CSF analysis using the abovementioned techniques may be useful in diagnosing neurosyphilis in these patients.

RESUMO La punción lumbar (PL) en pacientes VIH+ neurológicamente asintomáticos es controversial. Existen diferentes criterios para detectar en el líquido cefalorraquídeo (LCR) neurosífilis (NS): el examen Venereal Disease Research Laboratory (VDRL) en primer lugar, en caso de negatividad: la celularidad y el tenor de proteinas. Sin embargo el diagnóstico de NS puede ser sostenido a pesar de la negatividad de las técnicas mencionadas. La titulación del Treponema pallidum hemagglutination assay (TPHA) y la aplicación del índice de TPHA en Albúmina e Ig G mejoran la sensibilidad asociando elevado grado de especificidad. 32 pacientes fueron seleccionados para este estudio, el VDRL fue positivo en 5. El diagnóstico se elevó a 14 cuando se sumaron el resto de las técnicas. No se evidenció que la celularidad y el aumento de proteínas fueran herramientas auxiliares para el diagnóstico. De acuerdo a nuestro trabajo el estudio del LCR con las técnicas señaladas puede ser de utilidad en el diagnóstico de NS en estos pacientes.